A novel sulfate-bridged binuclear copper(ii) complex: structure, optical, ADMET and in vivo approach in a murine model of bone metastasis. (15th July 2021)

• Record Type: Journal Article
• Authors: Hchicha, Khouloud; Korb, Marcus; Badraoui, Riadh; Naïli, Houcine
• Is Part Of: New journal of chemistry. Volume 45:Number 31(2021)
• Page Start: 13775
• Page End: 13784
• Publication Date: 2021-07-15
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d1nj02388h
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A novel complex, formulated as [Cu2 (μ3 -SO4 )2 (C4 H6 N2 )4 ], showed significant ameliorative effects on tumor osteolytic lesions in malignant Walker 256/B breast cancer-induced bone metastases. Abstract : The novel sulfate-bridged binuclear copper(ii ) complex namely [Cu2 (μ3 -SO4 )2 (C4 H6 N2 )4 ] (1 ) was obtained from the hydrothermal reaction of 2-methylimidazole (hereafter abbreviated as 2-MeIm) with copper(ii ) sulfate pentahydrate in methanol. Single-crystal X-ray diffraction analysis of 1 (space group P 1̄; cell parameters: a = 8.5712(6) Å, b = 8.7884(10) Å, c = 9.8797(6) Å, α = 115.22(1)°, β = 97.26(1)°, γ = 108.82(1)° and V = 606.26(12) Å 3 ) revealed the formation of a centrosymmetric dimeric species. Therein, two [Cu(C4 H6 N2 )2 ] moieties are connected via two sulfate anions in a μ-1κ 2 O 1, O 2, 2κO 3 fashion and resulting in a tricyclo[5.1.1 3, 5 ] structure. The Cu atom adopts a distorted square pyramidal coordination geometry ( τ = 19). Hydrogen bonds between the imidazole amino groups and non-coordinating sulfato oxygen atoms result in a two-dimensional network parallel to (010). To accumulate a greater knowledge on how molecular components engage with their local environment, a Hirshfeld surface (HS) analysis employing 3D molecular surface contours and 2D fingerprint plots have been undertaken. Heating of 1 above 89 °C initiates gradual decomposition stages, which lead to the metal oxide as a final product at 720 °C, as proven by TGA/DSC analysis. UV-visible spectroscopy was exploited to determine bandgap energy and the nature of the electron transition. In vivo, the synthesized complex showed significant ameliorative effects on tumor osteolytic lesions in malignant Walker 256/B breast cancer-induced bone metastases.