Palladium-catalyzed dehydrogenative C–H cyclization for isoindolinone synthesis. Issue 43 (8th August 2021)

• Record Type: Journal Article
• Authors: Abe, Masahiro; Ueta, Kaho; Tanaka, Saki; Kimachi, Tetsutaro; Inamoto, Kiyofumi
• Is Part Of: RSC advances. Volume 11:Issue 43(2021)
• Page Start: 26988
• Page End: 26991
• Publication Date: 2021-08-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra04661f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Pd-catalyzed intramolecular dehydrogenative C(sp 3 )–H amidation for the synthesis of isoindolinones was developed. Use of Pd/C as a catalyst enables the desired cyclization to proceed smoothly without adding any stoichiometric oxidants. Abstract : In this paper Pd-catalyzed intramolecular dehydrogenative C(sp 3 )–H amidation for the synthesis of isoindolinones is described. This method features the use of a Pd/C catalyst and the addition of a stoichiometric amount of oxidant is not necessary. A mechanistic study suggested the possible formation of H2 gas during the reaction.