A metal–organic cage-based nanoagent for enhanced photodynamic antitumor therapy. Issue 64 (21st July 2021)

• Record Type: Journal Article
• Authors: Li, Wen-Yan; Zhao, Chao-Wei; Zhang, Yue-Feng; Guan, Qun; Wan, Jing-Jing; Ma, Jian-Ping; Li, Yan-An; Dong, Yu-Bin
• Is Part Of: Chemical communications. Volume 57:Issue 64(2021)
• Page Start: 7954
• Page End: 7957
• Publication Date: 2021-07-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc02629a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A Pd6 L8 (NO3 )5.4 (ICG)6.6 -based nanoagent (ICG = indocyanine green) displays a highly efficient antitumor activity due to its enhanced NIR light-triggered 1 O2 generation, high cellular uptake, and selective lysosome-targeting ability. Abstract : Herein, we report, for the first time, a Pd6 L8 (NO3 )5.4 (ICG)6.6 (ICG = indocyanine green) cage-based hexagonal nanoplate (3 ) via a combined nanoprecipitation and solid-state anion-exchange approach. Nanoplate 3 possesses enhanced near-infrared (NIR) light-triggered 1 O2 generation, high cellular uptake selective lysosome-targeting ability, and, consequently, excellent antineoplastic activity.