A Mn-catalyzed remote C(sp3)–H bond peroxidation triggered by radical trifluoromethylation of unactivated alkenes. Issue 63 (19th July 2021)

• Record Type: Journal Article
• Authors: Wang, Leilei; Ma, Yangyang; Jiang, Yuhang; Lv, Leiyang; Li, Zhiping
• Is Part Of: Chemical communications. Volume 57:Issue 63(2021)
• Page Start: 7846
• Page End: 7849
• Publication Date: 2021-07-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc03295j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A manganese-catalyzed remote peroxidation of C(sp 3 )–H bonds by a 1, 5-HAT mediated radical relay strategy was reported. Abstract : A manganese-catalyzed radical relay strategy for the remote trifluoromethylation–peroxidation of unactivated alkenes is disclosed. The electrophilic CF3 group was added to the CC double bonds to afford remote C-centered radicals upon 1, 5-HAT, which could be efficiently trapped by Mn n +1 OOBu- t species to deliver 1, 6-difunctionalized products selectively under mild conditions. t -BuOOH serves as both the oxidant and the peroxy precursor in this transformation.