A turn-on probe for detecting antituberculotic drug-induced liver injury in mice via NIR-II fluorescence/optoacoustic imaging. Issue 63 (19th July 2021)

• Record Type: Journal Article
• Authors: Chen, Longqi; Chen, Junjie; Fang, Yichang; Zeng, Fang; Wu, Shuizhu
• Is Part Of: Chemical communications. Volume 57:Issue 63(2021)
• Page Start: 7842
• Page End: 7845
• Publication Date: 2021-07-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc02845f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A turn-on probe has been devised for detecting antituberculotic-drug-induced liver injury via responding to the in situ biomarker hepatic H2 O2 with NIR-II fluorescence and MSOT imaging. Abstract : A turn-on optoacoustic and NIR-II fluorescent probe for imaging antituberculotic drug-induced liver injury has been developed. Probe TC-H2 O2 responds to hepatic H2 O2, thus releasing chromophore TC-NN, which displays prominent NIR-II fluorescence and optoacoustic signals for diagnosing liver injury.