A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to synthesize diphosphonyl xanthene derivatives. Issue 30 (15th July 2021)

• Record Type: Journal Article
• Authors: Fan, Tao; Liu, Yan; Jiang, Caina; Xu, Yanli; Chen, Yanyan
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 30(2021)
• Page Start: 6609
• Page End: 6612
• Publication Date: 2021-07-15
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob01045j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A cascade reaction of 2-aryloxy phenylacetylenes with phosphine oxides to provide diphosphonyl xanthenes promoted by K2 S2 O8 was developed. This reaction features transition metal-free and mild conditions, simple operation and good yields. Abstract : A radical cascade reaction of 2-aryloxy phenylacetylenes with phosphine oxides promoted by K2 S2 O8 was developed, which provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with simple operation and good yields. The mechanistic study indicated that phosphine oxide was induced into a phosphonyl radical, and then the following double radical addition/cyclization with 2-aryloxy phenylacetylenes generated bisphosphonyl xanthenes.