Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness. Issue 62 (8th July 2021)

• Record Type: Journal Article
• Authors: Chao, Shuang; Shen, Ziyan; Pei, Yuxin; Lv, Yinghua; Chen, Xiaolin; Ren, Jiaming; Yang, Ke; Pei, Zhichao
• Is Part Of: Chemical communications. Volume 57:Issue 62(2021)
• Page Start: 7625
• Page End: 7628
• Publication Date: 2021-07-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc02959b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A galactose-targeting supramolecular photosensitizer system DOX@GP5⊃NBSPD was constructed based on a host–guest inclusion complex, which could achieve the enhanced hypoxic-tumor therapeutic effectiveness by chemo-photodynamic combination. Abstract : A galactose-targeting supramolecular photosensitizer system DOX@GP5⊃NBSPD was constructed based on a host–guest inclusion complex. The supramolecular system could achieve efficient delivery of DOX/NBS and selective release under GSH stimulation. In vitro studies revealed that this supramolecular DOX/NBS co-delivery system exhibited high ROS production and excellent cancer cell damage capability in a hypoxic environment. This strategy can therefore achieve enhanced hypoxic-tumor therapeutic effectiveness by chemo-photodynamic combination.