P591 Neonatal diabetis. (June 2019) - Hmed, Amel Ben
Abstract : Background: Neonatal diabetes mellitus (NDM) is rare, noted in only 1 of every 300 000–400 000 live births. Both transient and permanent conditions have been described (TNDM and PNDM, respectively) which have different clinical, genetic features and outcomes. Cases presentation: Three newborns were included, 2 males and 1 female. The mean gestationnel age was: 35.3. All of them had born to consanguineous parents . The mean birth weight was 1506 g. Two patients had a family history of neonatal hyperglycemia. By the first week of life, glucose concentrations increased, Ketonuria and glycosuria were noted in two cases, the third patient had hyperglycemia, glycosuria without ketonuria at the age of 2 months. The serum insulin and C-peptide levels were low. Tests for anti-islet cell and anti-glutamic acid decarboxylase antibodies were all negative. Abdominal ultrasound was normal. The infants were diagnosed with NDM. Genetic testing was performed. Results are not yet available. All patients were managed with insulin therapy (1–2.5 UI/kg/J). During follow up Recurrent hospital admission for diabetic ketoacidosis were noted in two cases, but long term outcome was favorable. One patient had died. Conclusion: Neonatal diabetes mellitus is uncommon. It is important to distinguish neonatal diabetes mellitus from other causes of hyperglycemia in newborns. Early recognition and urgent genetic testing are important for predicting the clinical course and raising awareness of possible additional features.