Iodine and hypothyroidism in neonates with congenital heart disease. Issue 3 (1st November 1997)

• Record Type: Journal Article
• Authors: Linder, N; Sela, B; German, B; Davidovitch, N; Kuint, J; Hegesh, J; Lubin, D; Sack, J
• Is Part Of: Archives of disease in childhood. Volume 77:Issue 3(1997)
• Page Start: F239
• Page End: F240
• Publication Date: 1997-11-01
• Subjects: iodine -- hypothyroidism -- cardiac malformations -- catheterisation; Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/fn.77.3.F239
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : AIM: To evaluate the influence of the intravenous injection of iodine during cardiac catheterisation, and of topical iodine antiseptics during surgical procedures, on thyroid function in full term neonates. METHODS: Twenty one full term infants with major cardiac anomalies who survived for more than a month were studied. Thyroxine and thyrotropin concentrations were measured (by radioimmunoassay) before each procedure, 24 hours after the procedure, and every week thereafter until the age of 1 month or until normal. Thyroxine values less than 64.4 nmol/l were considered low, while thyrotropin values greater than 30 mU/l were considered high. RESULTS: Thyroid function tests before iodine exposure were within normal limits in all infants. Following catheterisation or surgery six infants had raised thyrotropin concentrations; three had low thyroxine concentrations. Two of those infants were treated with L-thyroxine. CONCLUSION: Iodine exposure during cardiac catheterisation or surgery may induce transient hypothyroidism in term infants.