Particulated Cartilage for Chondral and Osteochondral Repair: A Review. (December 2021)

• Record Type: Journal Article
• Authors: Christensen, Bjørn Borsøe; Olesen, Morten Lykke; Hede, Kris Tvilum Chadwick; Bergholt, Natasja Leth; Foldager, Casper Bindzus; Lind, Martin
• Is Part Of: Cartilage. Volume 13:Number 1(2022)Supplement
• Page Start: 1047S
• Page End: 1057S
• Publication Date: 2021-12
• Subjects: particulated cartilage -- minced cartilage -- cartilage chips -- cartilage repair -- repair -- particulated juvenile articular cartilage; Cartilage -- Periodicals; 616.7
• DOI: 10.1177/1947603520904757
• Languages: English
• ISSNs: 1947-6035

Abstract

Introduction: Injuries to articular cartilage have a poor spontaneous repair potential and no gold standard treatment exist. Particulated cartilage, both auto- and allograft, is a promising new treatment method that circumvents the high cost of scaffold- and cell-based treatments. Materials and Methods: A comprehensive database search on particulated cartilage was performed. Results: Fourteen animal studies have found particulated cartilage to be an effective treatment for cartilage injuries. Many studies suggest that juvenile cartilage has increased regenerative potential compared to adult cartilage. Sixteen clinical studies on 4 different treatment methods have been published. (1) CAIS, particulated autologous cartilage in a scaffold, (2) Denovo NT, juvenile human allograft cartilage embedded in fibrin glue, (3) autologous cartilage chips—with and without concomitant bone grafting, and (4) augmented autologous cartilage chips. Conclusion: Implantation of allogeneic and autologous particulated cartilage provides a low cost and effective treatment alternative to microfracture and autologous chondrocyte implantation. The methods are promising, but large randomized controlled studies are needed.