Association of MALAT-1 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus. (October 2021)

• Record Type: Journal Article
• Authors: Mao, Yan-Mei; He, Yi-Sheng; Wu, Guo-Cui; Hu, Yu-Qian; Xiang, Kun; Liao, Tao; Yan, Yu-Lu; Yang, Xiao-Ke; Shuai, Zong-Wen; Wang, Gui-Hong; Pan, Hai-Feng; Ye, Dong-Qing
• Is Part Of: Lupus. Volume 30:Number 12(2021)
• Page Start: 1923
• Page End: 1930
• Publication Date: 2021-10
• Subjects: Systemic lupus erythematosus -- long non-coding RNAs -- single-nucleotide polymorphisms -- MALAT-1; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/09612033211040366
• Languages: English
• ISSNs: 0961-2033

Abstract

Background: Abnormal expression and function of long non-coding RNAs (lncRNAs) are closely related to the pathogenesis of systemic lupus erythematosus (SLE). In this study, we aimed to investigate the association of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) gene single-nucleotide polymorphisms (SNPs) with susceptibility and clinical characteristics of SLE patients.Methods: A case-control study including 489 SLE patients and 492 healthy controls was conducted. Four MALAT-1 SNPs (rs4102217, rs591291, rs11227209, and rs619586) were genotyped in all subjects, their correlation with SLE susceptibility and clinical characteristics were also analyzed.Results: Results showed that the rs4102217 locus was associated with the risk of SLE. In recessive models, the GG+CG genotype of rs4102217 was associated with the decreased risk of SLE compared to CC ( p = 0.036, OR = 0.348, 95% CI: 0.124–0.975). In additive models, the GG genotype of rs4102217 was associated with the decreased risk of SLE compared to CC ( p = 0.040, OR = 0.355, 95% CI: 0.127–0.996). However, no association was found between MALAT-1 gene polymorphism and clinical manifestations of SLE (all p > 0.05).Conclusion: In summary, MALAT-1 rs4102217 is associated with susceptibility to SLE, suggesting that MALAT-1 may play a role in SLE.