Hepatitis C Treatment Outcomes in Persons With HIV and Decompensated Cirrhosis Using a Collaborative Multidisciplinary HIV-Centered Approach. (15th June 2021)

• Record Type: Journal Article
• Authors: Cachay, Edward R.; Mena, Alvaro; Morano, Luis; Benitez, Laura; Maida, Ivana; Mendoza, Carmen DE; Hill, Lucas; Torriani, Francesca; Soriano, Vincente; Mathews, W. C.
• Is Part Of: Journal of the International Association of Providers of AIDS Care. Volume 20(2021)
• Publication Date: 2021-06-15
• Subjects: HIV -- HCV -- liver decompensation -- DAA -- multidisciplinary; AIDS (Disease) -- Periodicals; 616.9792
• DOI: 10.1177/23259582211024771
• Languages: English
• ISSNs: 2325-9574

Abstract

Fifty-four consecutive persons with HIV co-infected with hepatitis C virus (HCV) and liver decompensation were treated with direct-acting antivirals (DAA). The HCV treatment was delivered using a multidisciplinary HIV-coinfection model of care integrating sub-specialty services in 3 countries. Of those treated, 91% (95% confidence interval, 80.1 to 95.9) achieved sustained viral response, and only one person died during treatment. Our study provides evidence that HIV providers achieve excellent outcomes when treating patients with histories of decompensated liver disease, with characteristics similar to those studied using a multidisciplinary HIV-centered approach.