Assessing the effect of human mesenchymal stem cell-derived conditioned media on human cancer cell lines: A systematic review. (August 2021)

• Record Type: Journal Article
• Authors: Raj, A. Thirumal; Kheur, Supriya; Bhonde, Ramesh; Gupta, Archana A; Patil, Shankargouda
• Is Part Of: Tissue & cell. Volume 71(2021)
• Publication Date: 2021-08
• Subjects: MSC Mesenchymal stem cells -- CM Conditioned media -- CM Mesenchymal stem cell derived conditioned media -- BMCM bone marrow derived CM -- ADCM Adipose derived CM -- UCCM Umbilical cord derived CM -- ACM Aminion derived CM -- GCM Gingiva derived CM -- DPCM Dental pulp derived CM -- WJCM Whartons Jelly derived CM -- FDCM Fetal dermis derived CM -- LCM Lung derived CM -- UTCCM Uterine cervix derived CM -- OCM Ovary derived CM -- IL Interleukins -- FGF Fibroblast growth factor -- VEGF Vascular endothelial growth factor -- PDGF- Platelet-derived growth factor -- TGFb1 Transforming growth factor -- IGF Insulin-like growth factor -- GRO Growth-regulated oncogene -- OSP Osteoprotegerin -- MMP Matrix metalloproteinases -- TNF Tumor necrosis factor -- MIP macrophage inflammatory protein -- MCP Monocyte chemoattractant protein -- MIG Monokine induced by IFN gamma -- IFN interferon -- IP IFN gamma inducible protein -- LAP latency-associated protein -- FRTK 3- Fms-related tyrosine kinase 3 ligands -- Tumor necrosis factor superfamily member 14 (also called LIGHT) -- GM-CSF Granulocyte-macrophage colony-stimulating factor -- RANTES Regulated on activation, normal T cell expressed and secreted -- HGF hepatocyte growth factor -- ETX Eotaxin -- DKK1 Dickkopf- 1 -- STAT Signal transducer and activator of transcription 3 -- ERK extracellular signal-regulated kinase -- PI3K Phosphoinositide 3-kinase -- mTOR- mammalian target of rapamycin -- EGFR epidermal growth factor receptor -- MAPK Mitogen-activated protein kinase -- ETIF4E Eukaryotic translation initiation factor 4E -- NF Kb- Nuclear factor kappa-light-chain-enhancer of activated B cells -- JAK Janus kinase -- Wnt Wingless-related integration site; Cancer -- Conditioned media -- Culture -- Mesenchymal stem cells; Cytology -- Periodicals; 571.5
• DOI: 10.1016/j.tice.2021.101505
• Languages: English
• ISSNs: 0040-8166

Abstract

Highlights: Anti and pro-carcinogenic MSC-CM were BM, UC, AD, WJ, DP, AM, and UT. CM from GMSC, FDMSC, and LMSC induced only anti-carcinogenic effect. CM from OMSC induced only a pro-carcinogenic effect. Abstract: Background: Mesenchymal stem cells (MSCs) exhibit differential effect (augmentation or inhibition) on cancer cells depending on the tissue of origin. Given the increasing demand to use MSCs in regenerative medicine, it is vital to ensure that the MSCs being employed are not pro-carcinogenic. Objective: To assess the effect of human MSC derived conditioned media (CM) on human cancer cell lines. Materials and methods: PubMed, SCOPUS, and Web of Science were searched using the keyword combination 'human mesenchymal stem cell and conditioned media and human cancer cell line and in-vitro'. Results: MSC-CM pro-carcinogenic molecules were IL-6, IL-8, FGF10, VEGF, PDGF, TGF-b1, IGF-1, GRO-a, OSP, MMPs, TNFα, IL-4, IL-10, IL-13, IL-17, IL-1 β, G-CSF, MCP‑1, MIP‑1α, MIP‑1β, RANTES, MIG, IP‑10, HGFa, ETX, DKK1; anti-carcinogenic molecules were IFN-β, OST, LIGHT, FRTK3, INF-γ, IP-10, LAP, IL‑1RA, IL‑2, IL-5, IL-7, IL-12, IL-15, IFN-α, IFN‑γ. Effector pathways were STAT 1, JAK2/STAT3, Ras–Raf–MEK–ERK, Wnt/β-catenin, NF-κB, ERK1/2, PI3K/ Akt/mTOR, MAPK/ERK. BMSC, ADMSC, UCMSC, WJMSC DPMSC, AMSC, and UTCMSC had a differential effect on carcinogenesis. GMSC, LMSC, FDMSC were anti-carcinogenic. OMSC was pro-carcinogenic. Conclusion: Use of MSC-CM with a pro-carcinogenic effect must be restricted in cancer patients irrespective of the nature of the application.