Challenges of pectic polysaccharides as a prebiotic from the perspective of fermentation characteristics and anti-colitis activity. (15th October 2021)

• Record Type: Journal Article
• Authors: Chengxiao, Yu; Dongmei, Wu; Kai, Zhu; Hou, Lijuan; Xiao, Hang; Ding, Tian; Liu, Donghong; Ye, Xingqian; Linhardt, Robert J.; Chen, Shiguo
• Is Part Of: Carbohydrate polymers. Volume 270(2021)
• Publication Date: 2021-10-15
• Subjects: IBD Inflammatory bowel disease -- UC Ulcerative colitis -- CD Crohn's disease -- FMT Fecal microbiota transplantation -- FOS Fructooligosaccharide -- GOS galactooligosaccharide -- PPS Pectic polysaccharides -- XOS Xylo-oligosaccharides -- SCFA short-chain fatty acids -- HG Homogalacturonan -- RG-I Rhamnogalacturonan I -- RG- II Rhamnogalacturonan II -- HM High methoxyl -- LM Low methoxyl -- DE Degree of esterification -- OTU operational taxonomic unit -- TJ Tight junction -- LPS Lipopolysaccharides -- ZO Zonula occludins -- HDAC histone deacetylase -- COX-2 Cyclooxygenase-2; Pectic polysaccharides -- Prebiotic -- Probiotic -- IBD; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2021.118377
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Several studies are described that contribute to the systematic exploration of new aspects of digestion, fermentation, and biological activities of pectic polysaccharides (PPS) leading to a better understanding of prebiotics. Inflammatory bowel disease (IBD) is thought to be associated with the dysbacteriosis induced by different environmental agents in genetically susceptible persons. PPS are considered as an indispensable gut-microbiota-accessible carbohydrate that play a dominant role in maintaining gut microbiota balance and show a better effect in ameliorating IBD than some traditional prebiotics. The aim of this review is to summarize the fermentation characteristics of PPS, highlight its role in improving IBD, and propose a view that PPS may be a new and effective prebiotic. Graphical abstract: Unlabelled Image Highlights: The development of models applied to pectic polysaccharides (PPS) is reviewed. Effect of PPS on inflammatory bowel disease (IBD) is discussed. Propose the potential of PPS as new prebiotic. The advantages and disadvantages of PPS on host compared to common prebiotics is summarized.