Angucyclines containing β-ᴅ-glucuronic acid from Streptomyces sp. KCB15JA151. (15th September 2021)

• Record Type: Journal Article
• Authors: Kim, Gil Soo; Jang, Jun-Pil; Oh, Tae Hoon; Kwon, Mincheol; Lee, Byeongsan; Lee, Jung-Sook; Ko, Sung-Kyun; Hong, Young-Soo; Ahn, Jong Seog; Jang, Jae-Hyuk
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 48(2021)
• Publication Date: 2021-09-15
• Subjects: Streptomyces sp. -- Angucycline -- β-ᴅ-Glucuronic acid; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2021.128237
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Two angucyclines, pseudonocardones D (1 ) and E (2 ), were isolated from Streptomyces sp. KCB15JA151. The planar structure was elucidated by comprehensive spectroscopic analysis. The absolute configuration of the sugar unit was determined based on the basis of coupling constants, ROESY, chemical derivatization and HPLC analysis. The biological activities of compounds 1 and 2 were examined by performing a computational target prediction, which led to tests of the antiestrogenic activity. The result suggested that compound 1 might be an ER α antagonist.