A comprehensive review of herbacetin: From chemistry to pharmacological activities. (28th October 2021)

• Record Type: Journal Article
• Authors: Wei, Xiaohan; Zhao, Zhejun; Zhong, Rongheng; Tan, Xiaomei
• Is Part Of: Journal of ethnopharmacology. Volume 279(2021)
• Publication Date: 2021-10-28
• Subjects: Herbacetin -- Flavonoids -- Pharmacokinetics -- Pharmacological activities; AUC Area under the curve -- AAPH 2, 2′-azobis (2-methylpropionamidine) dihydrochloride -- AP-1 activator protein-1 -- Bcl-2 B-cell lymphoma 2 -- Bax Bcl-2 associated x-protein -- BMMs bone marrow-derived macrophages -- Cmax maximum plasma concentration -- CPT carnitine palmitoyltransferase -- DFMO Difluoromethylornithine -- DMDO dimethyldioxirane -- DMSO dimethylulfoxide -- DPPH 1, 1-diphenyl-2-picryl-hydrazyl -- EGFR epidermal growth factor receptor -- ERK extracellular signal-regulated kinase -- FAS fatty acid synthase -- G6PD glucose 6-phosphate dehydrogenase -- HGF hepatocyte growth factor -- iNOS inducible NOS -- IL-1β interleukin-1β -- IC50 fifty percent inhibition -- JNK c-Jun N-terminal kinase -- LPS lipopolysaccharide -- MAPK mitogen-activated protein kinase -- MMP-9 matrix metalloproteinase-9 -- Met mesenchymal-epithelial transition factor -- NO nitric oxide -- NF-κB nuclear factor-κB -- NSAID nonsteroidal anti-inflammatory drug -- ODC ornithine decarboxylase -- PMCO primary mouse calvarial osteoblast -- PGE2 Prostaglandin E2 -- RANKL the receptor activator of nuclear factor-κB ligand -- ROS reactive oxygen species -- SREBPs terol regulatory element-binding proteins -- TNF-α tumor necrosis factor-α -- TLI, LPS TNF-α or/and IFN-γ -- TPA 12-O-tetradecanoylphorbol 13-acetate -- T2D type 2 diabetes mellitus -- β-oxidation fatty acid β-oxidation; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2021.114356
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: Herbacetin is an active constituent of traditional Chinese medicines such as Ephedra sinica Stapf (MaHuang) and Sedum roseum (L.). Scop. (Hong JingTian). MaHuang was used to treat cough, asthma, fever, and edema for more than 5000 years, while Hong JingTian was used to treat depression, fatigue, cancers, and cardiovascular disease. Recent studies indicate that herbacetin and its glycosides play a critical role in the pharmacological activities of these herbs. However, currently, no comprehensive review on herbacetin has been published yet. Aim of the study: This review aimed to summarize information on the chemistry, natural sources, and pharmacokinetic features of herbacetin, with an emphasis on its pharmacological activities and possible mechanisms of action. Materials and methods: A literature search was performed on the Web of Science, PubMed, and China Knowledge Resource Integrated databases (CNKI) using the search term "herbacetin" ("all fields") from 1935 to 2020. Information was also obtained from classic books of Chinese herbal medicine, Chinese pharmacopeia, and the database "The Plant List" (www.theplantlist.org ). Studies have been analyzed and summarized in this review if they dealt with chemistry, taxonomy, pharmacokinetic, and pharmacological activity. Results: Herbacetin is distributed in various plants and can be extracted or synthesized. It showed diverse pharmacological activities including antioxidant, antiviral, anti-inflammatory, anticancer, antidiabetic, and anticholinesterase. It is thought to have great potential in cancer treatment, especially colon and skin cancers. However, the bioavailability of herbacetin is low and the toxicity of herbacetin has not been studied. Thus, more studies are required to solve these problems. Conclusions: Herbacetin shows promising pharmacological activities against multiple diseases. Future research should focus on improving bioavailability, further studying its pharmacological mechanism, evaluating its toxicity and optimal dose, and performing the clinical assessment. We hope that the present review will serve as a guideline for future research on herbacetin. Graphical abstract: Image 1