Emerging functions of circular RNA in aging. Issue 9 (September 2021)

• Record Type: Journal Article
• Authors: Kim, Eunah; Kim, Yoon Ki; Lee, Seung-Jae V.
• Is Part Of: Trends in genetics. Volume 37:Issue 9(2021)
• Page Start: 819
• Page End: 829
• Publication Date: 2021-09
• Subjects: circular RNAs -- aging -- biomarker of aging -- senescence -- age-associated disease; Genetics -- Periodicals; 576.5
• DOI: 10.1016/j.tig.2021.04.014
• Languages: English
• ISSNs: 0168-9525

Abstract

Abstract : Circular RNA (circRNA) is a closed, single-stranded transcript widely detected in eukaryotes. Recent studies indicate that the levels of circRNAs change with age in various tissues in multiple species, ranging from nematodes to mammals. Here we discuss the functional roles of circRNAs in animal aging and longevity. We review studies regarding the differential expression of circRNAs that contributes to cellular senescence and the pathogenesis of aging-associated diseases. We explore the features of aging-associated circRNAs by discussing their potential as biomarkers of aging, tissue specificity, physiological roles, action mechanisms, and evolutionarily conserved characteristics. Our review provides insights into current progress in circRNA research and their significant functions in the aging process. Highlights: Circular RNAs (circRNAs) are closed and cyclic RNAs that are widely expressed in eukaryotes and have multiple functions, including interacting with proteins, sponging miRNAs, encoding proteins, and regulating gene expression via binding promoters. The expression patterns and stability of circRNAs have emerged as promising candidate biomarkers of aging and age-associated diseases. The levels of circRNAs generally increase with age in various species and may play roles in aging and cellular senescence. Specifically, ciRS-7/circCDR1as and circSfl are associated with Alzheimer's disease and fruit fly longevity, respectively. It will be important to identify functional circRNAs to elucidate the underlying mechanisms regarding their roles in aging and/or age-related diseases.