Volumetric growth of residual meningioma – A systematic review. (September 2021)

• Record Type: Journal Article
• Authors: Gillespie, Conor S.; Taweel, Basel A.; Richardson, George E.; Mustafa, Mohammad A.; Keshwara, Sumirat M.; Babar, Roshan K.; Alnaham, Khaleefa E.; Kumar, Siddhant; Bakhsh, Ali; Millward, Christopher P.; Islim, Abdurrahman I.; Brodbelt, Andrew R.; Mills, Samantha J.; Jenkinson, Michael D.
• Is Part Of: Journal of clinical neuroscience. Volume 91(2021)
• Page Start: 110
• Page End: 117
• Publication Date: 2021-09
• Subjects: EANO European Association of Neuro-Oncology -- GTR Gross total resection -- Frt Fractionated radiotherapy -- QUIPS Quality in Prognostic Studies -- SIGN Scottish Intercollegiate Guidelines Network -- SRS Stereotactic radiosurgery -- STR Subtotal resection -- WHO World Health Organisation; Meningioma -- Growth variables -- Residual -- Simpson grade -- Subtotal resection -- Systematic review -- Volume; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2021.06.033
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Volumetric growth of residual meningioma after surgery is not known. A systematic review is required to identify growth and associated variables. We identified only four retrospective studies in the literature, with varied growth rates reported. Highly powered, clinical studies are required to delineate growth of residual meningioma and associated prognostic factors. Abstract: Surgical resection of meningioma leaves residual solid tumour in over 25% of patients. Selection for further treatment and follow-up strategy may benefit from knowledge of volumetric growth and factors associated with re-growth. The aim of this review was to evaluate volumetric growth and variables associated with growth in patients that underwent incomplete resection of a meningioma without the use of adjuvant radiotherapy. A systematic review was conducted in accordance with the PRISMA statement and registered a priori with PROSPERO (registration number: CRD42020177052). Six databases were searched up to May 2020. Full text articles analysing volumetric growth rates in at least 10 patients who had residual meningioma after surgery were assessed. Four single-centre, retrospective studies totalling 238 patients were included, of which 99% of meningioma were WHO grade 1. The absolute tumour growth rate ranged from 0.09 to 4.94 cm 3 per year. The relative growth rate ranged from 5.11 to 14.18% per year. Varying methods of volumetric assessment and definitions of growth impeded pooled analysis. Pre-operative and residual tumour volume, and hyperintensity on T2 weighted MRI were identified as variables associated with residual meningioma growth, however this was inconsistent across studies. Risk of bias was high in all studies. Radiological regrowth occurred in 42–67% of cases. Our review identified that volumetric growth of residual meningioma is scarcely reported. Sufficiently powered studies are required to delineate volumetric growth and prognostic factors to stratify management.