Ecotoxicological effects of pyraclostrobin on tilapia (Oreochromis niloticus) via various exposure routes. (15th September 2021)

• Record Type: Journal Article
• Authors: Li, Hong; Jing, Tongfang; Li, Tongbin; Huang, Xueping; Gao, Yangyang; Zhu, Jiamei; Lin, Jin; Zhang, Peng; Li, Beixing; Mu, Wei
• Is Part Of: Environmental pollution. Volume 285(2021)
• Publication Date: 2021-09-15
• Subjects: Pyraclostrobin -- Acute toxicity pathway -- Gill -- Main target organ -- High toxic mechanism; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2021.117188
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Pyraclostrobin is a widely used and highly efficient fungicide that also has high toxicity to aquatic organisms, especially fish. Although some research has reported the toxic effects of pyraclostrobin on fish, the main toxic pathways of pyraclostrobin in fish remain unclear. The present study has integrated histopathological, biochemical and hematological techniques to reveal the main toxic pathways and mechanisms of pyraclostrobin under different exposure routes. Our results indicated that pyraclostrobin entered fish mainly through the gills. The highest accumulation of pyraclostrobin was observed in the gills and heart compared with accumulation in other tissues and gill tissue showed the most severe damage. Hypoxia symptoms (water jacking, tummy turning and cartwheel formation) in fish were observed throughout the experiment. Taken together, our results suggested that the gills are important target organs. The high pyraclostrobin toxicity to gills might be associated with oxidative damage to the gills, inducing alterations in ventilation frequency, oxygen-carrying substances in blood and disorders of energy metabolism. Our research facilitates a better understanding of the toxic mechanisms of pyraclostrobin in fish, which can promote the ecotoxicological research of agrochemicals on aquatic organisms. Graphical abstract: Image 1 Highlights: Different exposure pathways of pyraclostrobin shows different effects on fish. Gills are the important toxicity target organs for pyraclostrobin. Gill lesions can lead to oxidative damage and a series of toxicological effects. Abstract : Our results indicated that pyraclostrobin entered fish mainly via the gills by different exposure pathways and the gills were important target organs.