Long-term outcomes of patients following hospitalization for coronavirus disease 2019: a prospective observational study. (August 2021)

• Record Type: Journal Article
• Authors: Meije, Yolanda; Duarte-Borges, Alejandra; Sanz, Xavier; Clemente, Mercedes; Ribera, Alba; Ortega, Lucía; González-Pérez, Ruth; Cid, Roser; Pareja, Júlia; Cantero, Irene; Ariño, Miquel; Sagués, Teresa; LLaberia, Jaume; Ayestarán, Ana; Fernández-Hidalgo, Nuria; Candás-Estébanez, Beatriz; Alguersuari, N.; Arderiu, A.; Baeza, N.; Bugés, J.; Cabello, J.; Campillo, M.; Cantos, J.; Castellarnau, E.; Coco, A.; Coll, I.; Coroleu, D.; Costa, J.; Demestre, X.; Díez-Cascón, P.; Elizari, M.J.; Escape, I.; Espaulella, N.; Fabregat, J.; Ferré, C.; Ferrer, M.; Franco, F.; Galí, J.; García, E.; Garrillo, J.; Guzmán, C.; Iglesias, L.; Invernón, L.; Jimeno, J.; Lima, J.; León, M.; Martí, G.; Martínez, S.; Martínez-Agea, J.; Martínez-Fijo, L.; Martínez-Montauti, J.; Martínez-Trillos, A.; Mechó, S.; Méndez, A.; Mendiola, B.; Mercé, J.; Miranda, F.; Morillas, J.; Montané, M.; Musolas, A.; Odriozola, A.; Pagès, V.; Palau, J.; Palos, M.A.; Parra, E.; Pérez-Mas, J.R.; Pizurno, K.; Ponce, M.; Pons, S.; Redó, D.; Rodón, N.; Rodríguez-Froxán, G.; Santamaría, A.; Sitges, C.; Stasi, N.; Soler, J.M.; Torrens, A.; Vaqué, M.; Ventura, L.; Vericat, C.; Vila, A.;
• Is Part Of: Clinical microbiology and infection. Volume 27:Number 8(2021)
• Page Start: 1151
• Page End: 1157
• Publication Date: 2021-08
• Subjects: Aftermath -- Coronavirus disease 2019 -- Follow up -- Outpatient facility -- Pao2/Fio2 -- Sequelae; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2021.04.002
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: Objectives: Few data are available regarding follow up of patients with coronavirus disease 2019 (COVID-19) after their discharge. We aim to describe the long-term outcomes of survivors of hospitalization for COVID-19 followed up first at an outpatient facility and subsequently by telephone. Methods: Observational prospective study conducted at a tertiary general hospital. Clinical and radiological progression was assessed and data were recorded on a standardized reporting form. Patients were divided into three groups according to Pao 2 /Fio 2 at hospitalization: Pao 2 /Fio 2 >300, Pao 2 /Fio 2 300–200 and Pao 2 /Fio 2 <200. A logistic multivariate regression model was performed to identify factors associated with persistence of symptoms. Results: For facility follow up, 302 individuals were enrolled. Median follow up was 45 days after discharge; 78% (228/294) of patients had COVID-19-related symptoms (53% asthenia, 56% respiratory symptoms) and 40% (122/302) had residual pulmonary radiographic lesions. Pao 2 /Fio 2 <200 was an independent predictor of persistent dyspnoea (OR 1.87, 95% CI 1.38–2.52, p < 0.0001). Pao 2 /Fio 2 >300 was associated with resolution of chest radiographic lesions (OR 0.56, 95% CI 0.42–0.74, p < 0.0001). Fifty per cent of patients required specific medical follow up after the first consultation and were transferred to another physician . A total of 294 patients were contacted for telephone follow up after a median follow-up time of 7 months. Fifty per cent of patients (147/294) still presented symptoms and 49% (145/294) had psychological disorders. Asthenia was identified in 27% (78/294) and dyspnoea in 10% (28/294) of patients independently of Pao 2 /Fio 2 . Conclusions: Patients with COVID-19 require long-term follow up because of the persistence of symptoms; patients with low Pao 2 /Fio 2 during the acute illness require special attention. Graphical abstract: Image 1