AB0651 The effect of cyclophosphamide on pulmonary function and dependence on disease activity of interstitial lung disease associated with systemic sclerosis. (15th June 2017)

• Record Type: Journal Article
• Authors: Vonk, M; Hombergh, W van den; Knaapen, H; Simons, S; Fransen, J; Hoogen, F van den
• Is Part Of: Annals of the rheumatic diseases. Volume 76(2017)Supplement 2
• Page Start: 1280
• Page End: 1280
• Publication Date: 2017-06-15
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2017-eular.3441
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: The pathogenesis of interstitial lung disease associated with systemic sclerosis (SSc-ILD) is not completely elucidated, although it is believed that chronic alveolar inflammation leads to increasing fibrosis. Treatment strategies using cyclophosphamide (CYC) have been focusing on the inflammatory pathway of SSc-ILD. We hypothesized that CYC is more effective in patients that are in the early, inflammatory phase. Objectives: The objectives of this study are to analyze the effects of intravenously CYC pulses (750mg/m 2 ) on pulmonary function (FVC, DLCO) in SSc-ILD after 12, 24 and 36 months, and whether this effect is dependent on the extent of ILD, the proportion of ground glass compared to fibrosis, SSc disease duration or baseline DLCO <60%. Methods: Patients with SSc-ILD receiving CYC pulses between 2003 and 2015 were classified by the Goh (2008) criteria in either limited or extensive ILD, using HRCT at baseline independently judged by two raters. Pulmonary function tests were performed at 0, 6, 12, 24 and 36 months. Missing outcome data due to drop-out were replaced by last observation carried forward, except in case of death. Results: Seventy-five patients were included, 33 with limited ILD, 42 with extensive ILD. There were no baseline differences in age, gender, SSc subtype classification, disease duration or autoantibody status. Mean FVC and DLCO were stable after 12, 24 and 36 months of follow-up (figure 1). There was no effect in the degree of change in mean FVC and DLCO for the different effect modifiers (table 2): the extent of ILD, proportion of ground glass compared to fibrosis, short SSc disease duration or baseline DLCO <60%. Conclusions: Mean FVC and DLCO in SSc-related ILD was stable during 36 months of follow-up after cyclophosphamide pulse therapy. The extent of ILD, proportion of ground glass, SSc disease duration and baseline DLCO <60% did not influence the effect of CYC on pulmonary function. CYC did not appeare to be more effective in the early phase of SSc-ILD. Disclosure of Interest: None declared