AB0189 Raid composite index in the evaluation of ra patients receiving biological treatment: hur-bio real-life results. (15th June 2017)

• Record Type: Journal Article
• Authors: Erden, A; Kilic, L; Armagan, B; Sari, A; Akdogan, A; Bilgen, SA; Karadag, O; Ertenli, I; Kiraz, S; Kalyoncu, U
• Is Part Of: Annals of the rheumatic diseases. Volume 76(2017)Supplement 2
• Page Start: 1113
• Page End: 1113
• Publication Date: 2017-06-15
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2017-eular.4202
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Rheumatoid Arthritis Impact of Disease (RAID) is a composite index. There are seven domains of this index (pain, function, fatigue, sleep disturbance, physical wellbeing, psychological/emotional well-being and coping). Daily activity in last week is evaluated. This score, is reccommended to be used in clinical trials to measure the effect of RA. Objectives: The aim of this study is to examine the relationship between RAID composite index and other indexes. Methods: This study was carried out from the HUR-BIO reserved database since August, 2016. In addition to the demographic characteristics of the patients, DAS-28, HAQ-DI, pain, fatigue, Patient global Assesment (PGA), Tender joint counts (TJC), swollen joint counts (SJC), CRP and ESR are recorded. Since 2015, a RAID form is filled for our patients. While this composite scale was being created, Gazi University Turkey carried out Turkish validation, in the original study. RAID composite index includes 7 questions, each scored from 0 to 10, 0 being the best score while 10 points is worst. The relationship between RAID composite index and other indexes were studied with Spearman correlation test. Results: HUR-BIO database containts 1235 RA patients as of August 2016. A RAID form was filled for 149 of these patients before initiating biological agent. 124 patients (83.2%) were female. Mean age was 49±13 years and mean disease duration was 7.8±7.2 years. Positive ACPA and RF ratios were detected as 48/104 (45.7%) and 78/137 (56.9%) respectively. 77.9% of our patients had education of high school or less. RAID average score was detected as 6.72 (1.98). In female patients RAID disease activity was significantly higher than in men [RAID 6.8 (2.0) vs. 5.9 (1.6), p=0.038]. There was no significant difference among RF, CCP positive patients and auto antibody-negative patients in terms of RAID disease activity. [RAID for RF + vs -; 6.75 (2.05) vs 6.68 (1.86), p=0.82, RAID for CCP + vs -; 6.74 (1.96) vs 6.98 (1.82), p=0.52]. RAID disease activity measurements were correlated moderately acute phase reactants, it was very weak. In table, it is grouped by level of education and re-evaluated. In those with an education higher than college, rising parameters were seen in good level of correlation. [RAID vs Pain, r =0.65, p<0.005; RAID vs PGA, r =0.68, p<0.005]. Conclusions: RAID has low correlation with other composite index such as DAS-28 score. RAID also has moderate correlation with pain, fatigue ad PGA VAS. On the other hand, patient with high education level had better perception for those patient reported composite index. RAID can be used confidently in these selected cases. Disclosure of Interest: None declared