SAT0635 Descriptive analysis of the quanticap study: a multicentric prospective study for the validation of quantitative and qualitative parameters of nailfold capillaroscopy. (15th June 2017)

• Record Type: Journal Article
• Authors: Castellví, I; Reyner, P; Martinez, S; Moreno, M; Gelman, MS; Ortiz-Santamaría, V; Ordoñez, S; Santo, P; Heredia, S; Juanola, X; Corominas, H
• Is Part Of: Annals of the rheumatic diseases. Volume 76(2017)Supplement 2
• Page Start: 1014
• Page End: 1015
• Publication Date: 2017-06-15
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2017-eular.4408
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Nailfold capillaroscopy (NC) is a useful tool to study Raynaud's phenomenon (RP) and other diseases. Different findings and patterns has been described however there is currently no work that validates the qualitative and quantitative NC findings. Objectives: To describe the morphological and metrological findings of NC in patients with RP and autoimmune diseases. 2-Describe the morphological and metrological findings of CP in patients with RF and several systemic autoimmune diseases.To Describe the morphological and metrological findings of NC in patients with RP and other autoimmune diseases. Methods: Observational study performed in 10 hospitals by rheumatologists with experience in NC. Patients with diffuse systemic sclerosis (dSSc), limited systemic sclerosis (lSSc), dermatomyositis (DM), polimyositis (PM), systemic lupus erythematosus (SLE) Primary Sjögren's syndrome (PSS), rheumatoid arthritis (RA), primary RP and a control group without RP or rheumatological condition were collected.A video NC 200x magnification were made in all patients. 8 Fingers in each hand were analyzed to find: megacapillary and dilated capillaries, giant capillaries, loss of density (<7/mm), tortuous capillaries, ramifications, haemorrhages, thrombosis and destructuration. Also we analyzed the diameter of the afferent and efferent loop, the capillary apex, the capillary diameter and density/mm. The following variables were also collected: sex, age, years of evolution of the disease and RP, history of digital ulcers or medication for RP, smoking and presence of hypertension or diabetes. To compare qualitative variables, the test was used Chi-square or Fisher's test. To compare quantitative vs qualitative variables Student's T test was used. Significance was considered for those values with p<0.05. Results: Between May 2014 to December 2016 images of 406 patients were collected: 24 dSSc, 41 lSSc, 19 DM, 14 PM, 40 SLE, 39 PSS, 37 RA, 44 PRP and 145 controls. C 84.5% were women, the age of the sample were 51.32±15.21 years. 28.9% had a history of smoking and 21.1% and 5.5% of hypertension or diabetes, respectively. Excluding the cases of dSSc, lSSc, PRP and the 145 controls, the presence of RP was observed in 18/152 (11.84%). The afferent, efferent, apical diameter And capillary was 26.01±19.01; 31.93±24.51um; 37.95±36.67um and 82.68±58.10um respectively. The most frequent qualitative finding were tortuosities. The control group showed no difference in the presence of hypertension or diabetes except in patients with PM. We also observed more women in SLE and PSS patients vs control group and greater presence of digital ulcers in lSSc, dSSc, SLE and DM. Only the lSSc presented differences in the presence of tortuosities with respect to the control group. Conclusions: Except in the lSSc no differences were observed in the presence of tortuosities with the rest of groups and its presence may not be relevant in different diseases. Disclosure of Interest: None declared