FRI0102 Comparison of Diagnostic Accuracies of Anti-MCV and Anti-CCP Antibodies in Rheumatoid Arthritis: A Meta-Analysis. (9th June 2015)

• Record Type: Journal Article
• Authors: Lee, Y.H.; Song, G.G.
• Is Part Of: Annals of the rheumatic diseases. Volume 74(2015)Supplement 2
• Page Start: 456
• Page End: 456
• Publication Date: 2015-06-09
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2015-eular.1210
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Enhanced antibody reactivity against the mutated citrullinated vimentin (MCV) was found in the serum of RA patients compared to the citrullinated vimentin, and anti-MCV showed increased diagnostic accuracy. Anti-MCV has been studied in comparison to anti-cyclic citrullinated peptide (anti-CCP) with respect to diagnostic accuracy in rheumatoid arthritis (RA). However, it remains unclear if the overall diagnostic values of anti-MCV antibodies are comparable to anti-CCP antibodies. Objectives: The purpose of this study was to compare the diagnostic performance of anti-mutated citrullinated vimentin (anti-MCV) and anti-CCP antibodies in RA. Methods: We searched the Medline, Embase, and Cochrane library databases, and performed two meta-analyses on the diagnostic accuracy of anti-MCV and anti-CCP in patients with RA compared to healthy controls. Results: We identified 12 studies that included a total of 2, 003 RA patients and 831 controls for the meta-analysis. The pooled sensitivity and specificity of anti-MCV were 68.6% (95% confidence interval [CI] 66.6–79.7) and 94.2% (95% CI 92.4–96.7), and those of anti-CCP were 61.7% (95% CI 59.5–63.8) and 97.1% (95% CI 96.7–98.1), respectively. Anti-MCV PLR, NLR, and DOR were 12.99 (95% CI 8.013–21.27), 0.297 (95% CI 0.238–0.369), and 47.78 (95% CI 28.59–79.84), and those for anti-CCP were 16.71 (95% CI 11.42–24.47), 0.378 (95% CI 0.325–0.439), and 54.20 (95% CI 31.65–92.82), respectively. The AUC of anti-MCV was 0.886, and its Q * index was 0.817, indicating modest accuracy, while the AUC of anti-CCP was 0.946, and its Q * index was 0.885. The sensitivity of anti-MCV was significantly higher than that of anti-CCP in the diagnosis of RA (difference 0.069, 95% CI 0.039–0.098, p <0.0001), but the specificity of anti-MCV was lower than that of anti-CCP (difference −0.029, 95% CI −0.051–[−0.006], p =0.012). The Q * index of anti-MCV was significantly lower than that of anti-CCP (difference −0.068, 95% CI −0.070–[−0.065], p <0.0001). Conclusions: Our meta-analysis demonstrates that anti-MCV is more sensitive but less specific, and has lower diagnostic accuracy than anti-CCP in RA, although anti-MCV and anti-CCP showed comparable high PLRs. Disclosure of Interest: None declared