AB0820 Early Changes in Bone Markers Predict Response to Teriparatide in an Osteoporotic Portuguese Population. (10th June 2014)

• Record Type: Journal Article
• Authors: Fonseca, R.; Gonçalves, D.; Abelha-Aleixo, J.; Aguiar, F.; Madureira, P.; Vieira, R.; Terroso, G.; Bernardes, M.; Costa, L.
• Is Part Of: Annals of the rheumatic diseases. Volume 73:Supplement 2(2014)
• Page Start: 1074
• Page End: 1074
• Publication Date: 2014-06-10
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2014-eular.4623
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Short-term changes in biochemical markers of bone turnover have been suggested as predictors of long-term response in bone mass density (BMD) during teriparatide treatment. However, few data are available, particularly regarding increases in hip BMD. Objectives: The aim of this study was to examine whether early changes in biochemical markers of bone turnover predict long-term changes of BMD in patients treated with teriparatide. Methods: BMD values at baseline and 18 months were obtained with a LUNAR Expert 1320 R. β-C-telopeptide of collagen 1 crosslinks (β-CTX1), osteocalcin (OC), alkaline phosphatase and 25 (OH) vitamin D3 were measured at baseline, 3 and at 18 months. The association between baseline and 3 months markers levels and BMD changes at the end of treatment was evaluated using Spearman correlation analysis (SPSS 21.0). Results: Sixty three patients were evaluated. 92, 1% (58) were female and the mean age was 67, 65±8, 8 years. 60, 3% (38) had glucocorticoid-induced osteoporosis and/or secondary to chronic inflammatory diseases. After treatment median DMD changes were: 0, 088 g/cm 2 in lumbar spine (gain of 10, 65%), 0, 024 g/cm 2 in femoral neck (gain of 4, 16%), 0, 03g/cm 2 in wards triangle (gain of 7, 7%) and 0, 011g/cm 2 in total hip (gain of 1, 1%). At baseline, β-CTX1 and OC levels correlated positively with the variation of BMD in lumbar spine at 18 months (r =0, 452; p=0, 01 and r=0, 305; p=0, 04, respectively). Baseline OC levels also correlated significantly with BMD variation in femoral neck (r=0, 524; p<0, 01), wards triangle (r=0, 442; p=0, 02) and total hip (r=0, 364; p=0, 01). Statistically significant correlation was found between β-CTX1 level at 3 months and BMD variation in femoral neck (r=0, 389; p=0, 01) and wards triangle (r=0, 402; p=0, 03). 3 months OC levels correlated significantly with femoral neck DMO variation (r=0, 517; p<0, 01) and wards triangle DMO variation (r=0, 501; p<0, 01). No association was found between alkaline phosphatase and 25 (OH) vitamin D3 values at baseline and 3 months and BMD changes. Conclusions: In our study, we found an association between bone turnover markers levels at baseline and 3 months and final changes in BMD at the lumbar spine and total hip. The early measurement of bone turnover markers may be a useful tool to predict BMD response to this anabolic therapy. Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2014-eular.4623