OP0210-HPR Increase in Knee Muscle Strength is Associated with A Decrease in Activity Limitations in Patients with Established Knee Osteoarthritis: A 2 Years Follow-Up Study in the AMS-OA Cohort. (10th June 2014)

• Record Type: Journal Article
• Authors: Sanchez-Ramirez, D.C.; van der Leeden, M.; van der Esch, M.; Roorda, L.; Verschueren, S.; van Dieen, J.; Dekker, J.; Lems, W.
• Is Part Of: Annals of the rheumatic diseases. Volume 73:Supplement 2(2014)
• Page Start: 142
• Page End: 142
• Publication Date: 2014-06-10
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2014-eular.1360
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Osteoarthritis (OA) is considered a major cause of pain and activity limitations. Activity limitations are defined as difficulties in performing daily activities. Previous studies have shown a slow increase in activity limitations over time in patients with OA, while others have found no change or even a decrease in activity limitations in this group of patients. Nevertheless, there is a high between-patients variability in the course of activity limitations in patients with OA which needs to be further explained. Objectives: To examine the longitudinal association between knee muscle strength and activity limitations in patients with established knee osteoarthritis (OA), over two years. Methods: Data from 186 patients with knee OA part of the Amsterdam Osteoarthritis cohort were gathered at baseline and at two-year follow up. Knee extensor and knee flexor muscle strength were assessed using an isokinetic dynamometer. Activity limitations were assessed using Western Ontario and McMaster University Osteoarthritis Index (WOMAC) - Physical Function subscale, Get Up and Go test (GUG) and the stairs test. Uni- and multivariate linear regression analyses were used to assess the association between changes in muscle strength and changes in activity limitations, adjusting for relevant confounders and baseline activity limitations. Results: There was an overall 16% increase in mean knee muscle strength (p<0.001), 19% increase in knee extensor muscle strength (p<0.001) and 17% increase in knee flexor muscle strength (p<0.001), over two years. Increased average knee muscle strength and knee flexor muscle strength were associated with better self-reported physical function (WOMAC) (b=-5.7, p=0.03 and b=-6.2, p=0.05), decreased time performing the GUG (b=-1.2, p=0.003 and b=-1.4, p=0.05) and decreased time performing the stairs test (b=-4.4, p<0.001 and b=-6.6, p<0.001). Increased extensor muscle strength was only associated with decreased time performing the stairs test (b=-2.7, p<0.001). Conclusions: The increase of knee muscle strength is associated with decreased activity limitations in patients with knee OA, over two years. These results suggest that muscle strength partially explains the between-patients variability in activity limitations. Disclosure of Interest: None declared DOI: 10.1136/annrheumdis-2014-eular.1360