Gut and mind. Issue 7 (1st July 2003)

• Record Type: Journal Article
• Authors: Neary, N M; Small, C J; Bloom, S R
• Is Part Of: Gut. Volume 52:Issue 7(2003)
• Page Start: 918
• Page End: 921
• Publication Date: 2003-07-01
• Subjects: ghrelin -- peptide YY -- obesity -- growth hormone secretagogue receptor -- diabetes -- stomach; ARC, arcuate nucleus -- PYY, peptide YY -- GH, growth hormone -- GHSs, growth hormone secretagogues -- GHS-R, growth hormone secretagogue receptor -- PP, pancreatic polypeptide -- NPY, neuropeptide Y -- Agrp, agouti related protein -- POMC, proopiomelanocortin -- BMI, body mass index; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.52.7.918
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Obesity is a growing epidemic, causally associated with a number of serious medical conditions, including diabetes mellitus, coronary heart disease, and several cancers. The gut hormones ghrelin and peptide YY are secreted from the gut in response to changes to nutritional status. While food intake is stimulated by ghrelin, it is inhibited by peptide YY. The discovery, anatomy, and physiology of ghrelin and peptide YY are discussed, focusing on the adaptive changes in diseases such as obesity and anorexia nervosa. Ghrelin and PYY are important therapeutic targets in the quest to find an effective antiobesity treatment.