Argentaffin and argyrophil reactions and serotonin content of endocrine tumours. Issue 1 (January 1985)

• Record Type: Journal Article
• Authors: Wells, C A; Taylor, S M; Cuello, A C
• Is Part Of: Journal of clinical pathology. Volume 38:Issue 1(1985)
• Page Start: 49
• Page End: 53
• Publication Date: 1985-01
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.38.1.49
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Sixty carcinoid tumours were tested in a retrospective study with an immunoperoxidase technique using a monoclonal antibody against serotonin immunoreactive sites, with argyrophil staining using the Grimelius technique, and with argentaffin staining using the Masson-Fontana technique. A good correlation between all three techniques in the diagnosis of ileal carcinoid tumour was found, but the immunoperoxidase technique showed greater sensitivity than the Masson-Fontana technique and greater specificity than the Grimelius technique in the diagnosis of foregut and hindgut carcinoid tumours. The immunoperoxidase technique with a monoclonal antibody against serotonin immunoreactive sites (YC5/45) is recommended as a sensitive and specific test for carcinoid tumours. The reactions in other endocrine tumours are also included.