A 5-hydroxytryptophan-secreting carcinoid tumour. Issue 1 (March 1963)

• Record Type: Journal Article
• Authors: Campbell, A. C. P.; Gowenlock, A. H.; Platt, D. S.; Snow, P. J. D.
• Is Part Of: Gut. Volume 4:Issue 1(1963)
• Page Start: 61
• Page End: 67
• Publication Date: 1963-03
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.4.1.61
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : An atypical case of the malignant carcinoid syndrome, associated with multiple peptic ulcers, is described. The tumour cells were argyrophil but not argentaffin, and the tumour was found to contain 5-hydroxytryptophan (5-H.T.P.) but not 5-hydroxytryptamine (5-H.T.). This aberrant biochemical behaviour was associated with the virtual absence of 5-H.T.P.-decarboxylase from the tumour tissue. The tumour contained notable quantities of histamine.