Localisation of a new gene for non-specific mental retardation to Xq22-q26 (MRX35). Issue 1 (January 1996)

• Record Type: Journal Article
• Authors: Gu, X X; Decorte, R; Marynen, P; Fryns, J P; Cassiman, J J; Raeymaekers, P
• Is Part Of: Journal of medical genetics. Volume 33:Issue 1(1996)
• Page Start: 52
• Page End: 55
• Publication Date: 1996-01
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.33.1.52
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : Non-specific mental retardation (MR) is a condition in which MR appears to be the only consistent manifestation. The X linked form (MRX) is genetically heterogeneous. We report clinical, cytogenetic, and linkage data on a family with X linked non-specific MR. Two point and multi-point linkage analysis with 18 polymorphic markers, covering the entire chromosome, showed close linkage to DXS1001 and DXS425 with a maximal lod score of 2.41 at 0% recombination. DXS178 and the gene for hypoxanthine phosphoribosyl-transferase (HPRT), located in Xq22 and Xq26 respectively, flank the mutation. All other chromosomal regions could be excluded with odds of at least 100:1. To our knowledge there is currently no other non-specific MR gene mapped to this region. Therefore, the gene causing MR in this family can be considered to be a new, independent MRX locus (MRX35).