Effect of treatment on Campylobacter pylori in peptic disease: a randomised prospective trial. Issue 3 (March 1988)

• Record Type: Journal Article
• Authors: Humphreys, H; Bourke, S; Dooley, C; McKenna, D; Power, B; Keane, C T; Sweeney, E C; O'Moráin, C
• Is Part Of: Gut. Volume 29:Issue 3(1988)
• Page Start: 279
• Page End: 283
• Publication Date: 1988-03
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.29.3.279
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : This study investigated the effect of colloidal bismuth subcitrate and cimetidine on Campylobacter pylori in peptic disease. In 74% of 135 patients with peptic disease diagnosed at endoscopy C pylori was detected before treatment. Compared with cimetidine, colloidal bismuth subcitrate significantly decreased the incidence of C pylori after six weeks of treatment (p less than 0.001). In the colloidal bismuth subcitrate group, subsequent healing of the lesion was correlated with the clearance of C pylori, unlike in the cimetidine group. C pylori was strongly associated with the presence of histological gastritis, which was decreased by colloidal bismuth subcitrate (p less than 0.001).