A placental chorionic villous mesenchymal core cellular origin for infantile haemangioma. Issue 10 (22nd September 2011)

• Record Type: Journal Article
• Authors: Itinteang, Tinte; Tan, Swee T; Guthrie, Siobhan; Tan, Cherise E S; McIntyre, Ben C; Brasch, Helen D; Day, Darren J
• Is Part Of: Journal of clinical pathology. Volume 64:Issue 10(2011)
• Page Start: 870
• Page End: 874
• Publication Date: 2011-09-22
• Subjects: Apoptosis -- biological sciences -- cancer -- cancer research -- cell biology -- chorionic gonadotrophin -- endothelium -- head and neck -- head and neck cancer -- human -- immunocytochemistry -- infantile haemangioma -- lactogen -- leucocyte antigen -- placental chorionic villous mesenchymal core -- surgical pathology -- trophoblast -- tumour angiogenesis -- tumour biology -- tumour markers; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jclinpath-2011-200191
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Aims: To investigate the expression of the placental cell-specific associated proteins in infantile haemangioma (IH). Methods: Immunohistochemical staining was used to investigate the expression of human chorionic gonadotrophin (hCG), human placental lactogen (hPL), human leucocyte antigen-G (HLA-G), cytokeratin 7 (CK7) and smooth muscle actin in paraffin-embedded sections of proliferating and involuted IHs. Results: The proteins hCG and hPL were expressed by the endothelium but not the pericyte layer of proliferating IH, but these proteins were not detected in involuted lesions. There was no expression of CK7 and HLA-G in IH. Conclusions: The expression of hCG and hPL, but not CK7 or HLA-G, by the endothelium of proliferating IH supports a placental chorionic villous mesenchymal core cellular origin for IH rather than a trophoblast origin.