Cyclosporin in the treatment of corticosteroid resistant autoimmune chronic active hepatitis. Issue 3 (March 1995)

• Record Type: Journal Article
• Authors: Jackson, L D; Song, E
• Is Part Of: Gut. Volume 36:Issue 3(1995)
• Page Start: 459
• Page End: 461
• Publication Date: 1995-03
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.36.3.459
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : A 17 year old Asian patient with autoimmune chronic active hepatitis resistant to treatment with high dose corticosteroids and azathioprine was given cyclosporin at a dose of 5 mg/kg/day. Within two weeks of starting the cyclosporin treatment a favourable clinical and biochemical response was obtained and by one month serum aminotransferase activities were within normal limits. An attempted reduction in the daily dose of cyclosporin resulted in a relapse of the patient's disease. Remission was again attained by returning the dose of cyclosporin to 5 mg/kg/day. No significant side effects of the treatment have been shown. Cyclosporin seems to have a role in the treatment of corticosteroid resistant autoimmune chronic active hepatitis and its further evaluation is warranted.