Long-term change in alcohol-consumption status and variations in fibrinogen levels: the coronary artery risk development in young adults (CARDIA) study. Issue 7 (11th July 2013)

• Record Type: Journal Article
• Authors: Okwuosa, Tochi M; Klein, Oana; Chan, Cheeling; Schreiner, Pamela; Liu, Kiang; Green, David
• Is Part Of: BMJ open. Volume 3:Issue 7(2013)
• Publication Date: 2013-07-11
• Subjects: Epidemiology -- Preventive Medicine; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2013-002944
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objective: To examine long-term associations between change in alcohol-consumption status and cessation of alcohol use, and fibrinogen levels in a large, young, biracial cohort. Design: Analysis of covariance models were used to analyse participants within the Coronary Artery Risk Development in Young Adults Study (CARDIA) cohort who had fibrinogen and alcohol use data at year 7 (1992–1993; ages 25–37) and year 20 examinations. Setting: 4 urban US cities. Patients: 2520 men and women within the CARDIA cohort. Main outcome measures: 13-year changes in alcohol use related to changes in fibrinogen. Results: Over 13 years, mean fibrinogen increased by 71 vs 70 mg/dL (p=NS) in black men (BM) versus white men (WM), and 78 vs 68 mg/dL (p<0.05) in black women (BW) versus white women (WW), respectively. Compared with never-drinkers, there were smaller longitudinal increases in fibrinogen for BM, BW and WW (but a larger increase in WM) who became or stayed drinkers, after multivariable adjustment. For BM, WM and WW, fibrinogen increased the most among persons who quit drinking over 13 years (p<0.001 for WM (fibrinogen increase=86.5 (7.1) (mean (SE))), compared with never-drinkers (fibrinogen increase=53.1 (5.4)). Conclusions: In this young cohort, compared with the participants who never drank, those who became/stayed drinkers had smaller increases, while those who quit drinking had the highest increase in fibrinogen over 13 years of follow-up. The results provide a novel insight into the mechanism for the established protective effect of moderate alcohol intake on cardiovascular disease outcomes.