Effect of cigarette smoking on the lower oesophageal sphincter. Issue 10 (October 1977)

• Record Type: Journal Article
• Authors: Chattopadhyay, D K; Greaney, M G; Irvin, T T
• Is Part Of: Gut. Volume 18:Issue 10(1977)
• Page Start: 833
• Page End: 835
• Publication Date: 1977-10
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.18.10.833
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Observations on the effect of smoking on lower oesophageal sphincter pressure (LOSP) are based on station pull-through techniques of eosophageal manometry and recent studies have suggested that these techniques are inaccurate. Reproducible measurements of LOSP may be achieved with a rapid pull-through (RPT) method of manometry. This method was used to determine the effect of cigarette smoking on LOSP in 10 asymptomatic volunteers and in a group of 10 patients with symptoms of gastro-oesophageal reflux. Basal LOSP measurements in the two groups were not significantly different but LOSP was reduced by 19% in asymptomatic subjects (p less than 0-01) and by 21% in symptomatic patients (p less than 0-02) during cigarette smoking. The results suggest that smoking should be avoided in the clinical management of gastro-oesophageal reflux.