Recruitment and plasmapheresis of donors to provide human antitetanus immunoglobulin. Issue 3 (March 1976)

• Record Type: Journal Article
• Authors: Cook, I A; Ross, D W; Gordon, I
• Is Part Of: Journal of clinical pathology. Volume 29:Issue 3(1976)
• Page Start: 211
• Page End: 214
• Publication Date: 1976-03
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.29.3.211
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : A method is described whereby about 100 litres of plasma containing 10-50 IU/ml tetanus antitixin was obtained, from which were prepared 5000 X 250 IU doses of human antitetanus immunoglobulin. Of 40 blood donors who received a booster injection of tetanus vaccine BP, 33 were plasmapheresed each week over a 10-12 week period starting three weeks after the injection. Twenty-two of these donors provided 90% of the total plasma, the antitoxin content of which averaged 23.6 IU/ml over the 10-12 week period.