Frequency of pancreatitis in fulminant hepatic failure using isoenzyme markers. Issue 6 (June 1988)

• Record Type: Journal Article
• Authors: Ede, R J; Moore, K P; Marshall, W J; Williams, R
• Is Part Of: Gut. Volume 29:Issue 6(1988)
• Page Start: 778
• Page End: 781
• Publication Date: 1988-06
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.29.6.778
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Evidence of acute pancreatitis was sought in 35 patients with fulminant hepatic failure. Total amylase was raised in 22 patients and isoenzyme separation showed a distinct P3 isoenzyme (indicative of pancreatitis) in 14. In four patients with marked hyperamylasaemia (greater than 1000 U/l) the predominant isoenzyme was the salivary fraction. Pancreatic lipase was abnormally raised (greater than 200 U/l) in 34 patients but exceeded 1000 U/l in 12 of the 14 with a distinct P3 isoenzyme. Thus on the basis of a distinct P3 isoenzyme of amylase and an increased pancreatic lipase activity evidence of pancreatitis was found in 34% of patients in this series.