Osteogenesis imperfecta (lethal) bones contain types III and V collagens. Issue 6 (June 1980)

• Record Type: Journal Article
• Authors: Pope, F M; Nicholls, A C; Eggleton, C; Narcissi, P; Hey, E N; Parkin, J M
• Is Part Of: Journal of clinical pathology. Volume 33:Issue 6(1980)
• Page Start: 534
• Page End: 538
• Publication Date: 1980-06
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.33.6.534
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Lethal osteogenesis imperfecta (OI-L) and normal fetal bones contain types I and V collagen with relatively more type V in OI-L bones. The latter, unlike normal fetal bone, also contain some type III collagen. Such altered collagen ratios could directly produce the bony fragility and radiotranslucency of OI-L bones. Since this is an inherited osteoporosis similar alterations in acquired osteoporoses are also possible.