1, 25-dihydroxycholecalciferol in renal osteodystrophy. Epiphysiolysis--anticonvulsant therapy. Issue 6 (June 1977)

• Record Type: Journal Article
• Authors: Pierides, A M; Ellis, H A; Dellagrammatikas, H; Scott, J E; Norman, A W
• Is Part Of: Archives of disease in childhood. Volume 52:Issue 6(1977)
• Page Start: 464
• Page End: 472
• Publication Date: 1977-06
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.52.6.464
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Three children with azotaemic renal osteodystrophy were treated with 1, 25-dihydroxycholecalciferol (1, 25(OH)2D3). All showed clinical, biochemical, and radiological improvement within 6 months of starting treatment. There were no complications. The dose of 1, 25(OH)2D3 required was 0-5 microgram per day for 2 children aged 22 and 30 months, and 2 microgram per day for a 15-year-old boy. 2 of the patients were receiving phenobarbitone and phenytoin and in one of them prior treatment with dihydrotachysterol 0-5 mg daily and 6 microgram 1alpha-hydroxycholecalciferol (1alphaOHD3) daily had failed to induce improvement. In one patient, in whom serial iliac bone samples were available, 2 microgram 1, 25(OH)2D3 resulted in histological improvement in previously severe osteomalacia. 1, 25(OH)2D3 appears to be an effective and safe drug in the treatment of uraemic osteodystrophy.