Dose-Finding Methodology for Peripheral Nerve Blocks. Issue 6 (1st November 2014)

• Record Type: Journal Article
• Authors: Saranteas, Theodosios; Finlayson, Roderick J.; Tran, De Q. H.
• Is Part Of: Regional anesthesia and pain medicine. Volume 39:Issue 6(2014)
• Page Start: 550
• Page End: 555
• Publication Date: 2014-11-01
• Subjects: Conduction anesthesia -- Periodicals; Pain medicine -- Periodicals; 617.964
• DOI: 10.1097/AAP.0000000000000157
• Languages: English
• ISSNs: 1098-7339

Abstract

Abstract : Abstract: Dose-finding studies enable the successful conduct of peripheral nerve blocks by ensuring the administration of appropriate doses of local anesthetic. However, the optimal dose-finding methodology remains ambiguous. In this research methodology article, we set out to review the basic aspects pertaining to dose-response curves (graded vs quantal), the pharmacodynamic indices required by dose-finding studies, the properties of different dose-finding methods (sigmoidal dose-response curve analysis, Dixon-Mood method, Biased Coin Design, and Bayesian analysis), as well as strategies and recommendations for future research.