"Therapeutic" serum concentration of phenytoin: the influence of seizure type. Issue 3 (March 1984)

• Record Type: Journal Article
• Authors: Turnbull, D M; Rawlins, M D; Weightman, D; Chadwick, D W
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 47:Issue 3(1984)
• Page Start: 231
• Page End: 234
• Publication Date: 1984-03
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.47.3.231
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Serum phenytoin concentrations were monitored prospectively in 26 patients with previously untreated partial epilepsy, during monotherapy with phenytoin. Only six remained entirely seizure-free, although only four experienced further tonic-clonic seizures. There was no correlation between serum phenytoin concentrations and freedom from partial seizures in those patients in whom such seizures recurred. There did appear to be a correlation between serum phenytoin concentration and freedom from tonic-clonic seizures.