HPV self-sampling acceptability in rural and indigenous communities in Guatemala: a cross-sectional study. Issue 10 (28th October 2019)

• Record Type: Journal Article
• Authors: Murchland, Audrey R.; Gottschlich, Anna; Bevilacqua, Kristin; Pineda, Andres; Sandoval-Ramírez, Berner Andrée; Alvarez, Christian S; Ogilvie, Gina S; Carey, Thomas E; Prince, Mark; Dean, Michael; Mendoza Montano, Carlos; Rivera-Andrade, Alvaro; Meza, Rafael
• Is Part Of: BMJ open. Volume 9:Issue 10(2019)
• Publication Date: 2019-10-28
• Subjects: public health -- epidemiology -- public health -- epidemiology -- epidemiology; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2019-029158
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: Cervical cancer disproportionately burdens low-income and middle-income countries (LMICs) such as Guatemala. Self-collection testing for human papillomavirus (HPV) has been suggested as a form of cervical cancer screening to facilitate access in LMICs. This study assessed and compared the acceptability of self-collection HPV testing in two rural, indigenous and ethnically distinct communities in Guatemala: Santiago Atitlán, Sololá and Livingston, Izabal. Methods: All participants, women between the ages of 18 and 60, completed a questionnaire. Eligible participants were also asked to self-collect a vaginal sample and complete a questionnaire regarding comfort and acceptability. Self-collected samples were tested for high-risk HPV using the real-time PCR Hybribio kit. Results: In the indigenous community of Santiago Atitlán, of 438 age-eligible participants, 94% completed self-collection. Of those, 81% found it comfortable and 98% were willing to use it as a form of screening. In the multiethnic (Afro-Caribbean, indigenous) community of Livingston, of 322 age-eligible participants, 53% chose to self-collect. Among those who took the test, 83% found it comfortable and 95% were willing to use it as a form of screening. In Livingston, literacy (can read and/or write vs cannot read or write) was higher in women who chose to self-collect (prevalence ratio 2.25; 95% CI 1.38 to 3.68). Ethnicity, history of screening and reproductive history were not associated with willingness to self-collect in Livingston. Women in Santiago reported less prior use of healthcare than women in Livingston. Overall, 19% (106/549) of samples tested positive for high-risk HPV. Conclusion: Among women willing to self-collect in rural and indigenous communities in Guatemala, self-collection for HPV testing is highly acceptable. However, willingness to try self-collection might vary across communities and settings. Women from a community that used less healthcare were more likely to choose self-collection. Further research is necessary to determine what factors influence a woman's choice to self-collect.