Infant T‐cell acute lymphoblastic leukaemia with t(6;7) (TCRB‐MYB) translocation. (1st July 2021)

• Record Type: Journal Article
• Authors: Ramdeny, Pemantah Sandheeah; Mullanfroze, Khushnuma; de Lorenzo, Paola; Grazia Valsecchi, Maria; Meijerink, Jules; Pieters, Rob; Baruchel, Andre; Vora, Ajay
• Is Part Of: British journal of haematology. Volume 194:Number 3(2021)
• Page Start: 613
• Page End: 616
• Publication Date: 2021-07-01
• Subjects: infant -- T‐Acute Lymphoblastic Leukaemia; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.17609
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: T‐ALL is rare in infancy with only 10 (1.5%) of 651 patients of that subtype in the Interfant‐06 infant ALL trial. We report 3 cases of t(6;7) (TCR/MYB) infant T‐cell Acute Lymphoblastic Leukaemia who appear to have a distinct clinical presentation with CNS disease and refractory disease or late relapse.