Animal models for SARS‐CoV‐2 research: A comprehensive literature review. Issue 4 (20th December 2020)

• Record Type: Journal Article
• Authors: Pandey, Kabita; Acharya, Arpan; Mohan, Mahesh; Ng, Caroline L.; Reid, St Patrick; Byrareddy, Siddappa N.
• Is Part Of: Transboundary and emerging diseases. Volume 68:Issue 4(2021)
• Page Start: 1868
• Page End: 1885
• Publication Date: 2020-12-20
• Subjects: animal model -- ferret -- hamster -- macaque -- mice -- pathophysiology -- SARS‐CoV‐2; Veterinary medicine -- Periodicals; 636.089
• DOI: 10.1111/tbed.13907
• Languages: English
• ISSNs: 1865-1674

Abstract

Abstract: Emerging and re‐emerging viral diseases can create devastating effects on human lives and may also lead to economic crises. The ongoing COVID‐19 pandemic due to the novel coronavirus (nCoV), severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which originated in Wuhan, China, has caused a global public health emergency. To date, the molecular mechanism of transmission of SARS‐CoV‐2, its clinical manifestations and pathogenesis is not completely understood. The global scientific community has intensified its efforts in understanding the biology of SARS‐CoV‐2 for development of vaccines and therapeutic interventions to prevent the rapid spread of the virus and to control mortality and morbidity associated with COVID‐19. To understand the pathophysiology of SARS‐CoV‐2, appropriate animal models that mimic the biology of human SARS‐CoV‐2 infection are urgently needed. In this review, we outline animal models that have been used to study previous human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS‐CoV) and middle east respiratory syndrome coronavirus (MERS‐CoV). Importantly, we discuss models that are appropriate for SARS‐CoV‐2 as well as the advantages and disadvantages of various available methods.