Gallbladder cancer epidemiology, treatment and survival in Southern Finland – a population-based study. (3rd August 2021)

• Record Type: Journal Article
• Authors: Koppatz, Hanna; Takala, Sini; Peltola, Katriina; But, Anna; Mäkisalo, Heikki; Nordin, Arno; Sallinen, Ville
• Is Part Of: Scandinavian journal of gastroenterology. Volume 56:Number 8(2021)
• Page Start: 929
• Page End: 939
• Publication Date: 2021-08-03
• Subjects: Incidence -- biliary tract cancer -- neoplasm; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.1080/00365521.2021.1915373
• Languages: English
• ISSNs: 0036-5521

Abstract

Abstract: Introduction: Gallbladder cancer (GBC) is a rare malignancy in Western population with poor prognosis. This study aimed to investigate the trends in GBC incidence, treatment pattern, and survival in Finland. Methods: Patients diagnosed with primary GBC in a geographically defined area (Southern Finland Regional Cancer Center) during 2006–2017 were identified. Results: Final cohort included 270 patients with GBC. The incidence was 1.32/100, 000 persons, and it decreased 6.8 cases per million personyears during the study period. One hundred fifty-one (56%) patients were diagnosed at Stage IV. Fifty-one patients (19%) underwent curative-intent resection with 96% R0-resection rate. The median overall survival was 7.1 months and 5-year overall survival 11.6% for all patients, and 67.7 months and 56.8% after curative-intent resection, respectively. No improvement was noted over time in overall survival in patients with GBC, or in subgroups of different stages of GBC. Conclusions: The incidence of GBC is slightly decreasing in Southern Finland, but survival has not improved over time.