Severe Hypotony Maculopathy in Anterior Uveitis Associated with Hodgkin Lymphoma. (3rd April 2021)

• Record Type: Journal Article
• Authors: Marchese, Alessandro; Giuffrè, Chiara; Miserocchi, Elisabetta; Cicinelli, Maria Vittoria; Bandello, Francesco; Modorati, Giulio
• Is Part Of: Ocular immunology and inflammation. Volume 29:Number 3(2021)
• Page Start: 460
• Page End: 464
• Publication Date: 2021-04-03
• Subjects: Hodgkin lymphoma -- hypotony maculopathy -- ibopamine -- ocular hypotony -- uveitis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2019.1668952
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To describe the clinical course and management of anterior uveitis complicated by ocular hypotony associated with Hodgkin lymphoma. Design : Case report. Methods : Chart and multimodal imaging review, including ultrasound biomicroscopy, widefield fundus pictures, fundus autofluorescence, fluorescein angiography, and indocyanine green angiography. Results : A 44-year-old female with progressive visual deterioration and history of low-grade fever developed bilateral granulomatous anterior uveitis complicated by severe hypotony maculopathy, not improving with systemic and topical steroids. After starting ibopamine 2% eye drops, ocular hypotony progressively resolved with visual recovery. Histologic examination of a biopsied enlarged lymph node of the neck revealed the presence of Hodgkin lymphoma, for which the patient underwent systemic chemotherapy. Conclusion : Severe hypotony maculopathy complicating anterior uveitis can be associated with Hodgkin lymphoma. Topical ipobamine 2% was safe and effective in the treatment of ocular hypotony in this case.