The copper-catalyzed synthesis of dihydrooxazoles from α, β-unsaturated ketoximes and activated ketones. Issue 59 (1st July 2021)

• Record Type: Journal Article
• Authors: Rong, Binsen; Xu, Gaochen; Yan, Huan; Zhang, Sai; Wu, Qinghuan; Zhu, Ning; Duan, Jindian; Guo, Kai
• Is Part Of: Chemical communications. Volume 57:Issue 59(2021)
• Page Start: 7272
• Page End: 7275
• Publication Date: 2021-07-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc02422a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A copper-catalyzed [3+2]-type condensation reaction between α, β-unsaturated ketoximes and activated ketones for the synthesis of dihydrooxazoles is described. Abstract : The first copper-catalyzed [3+2]-type condensation reaction of α, β-unsaturated ketoximes with activated ketones has been described for the synthesis of dihydrooxazoles, especially trifluoromethyl-decorated dihydrooxazoles. Notable features of this method include its broad substrate scope, good functional group tolerance, and simple operation.