Stretch-responsive adhesive microcapsules for strain-regulated antibiotic release from fabric wound dressings. (5th July 2021)

• Record Type: Journal Article
• Authors: Jo, Yun Kee; Heo, Su-Jin; Peredo, Ana P.; Mauck, Robert L.; Dodge, George R.; Lee, Daeyeon
• Is Part Of: Biomaterials science. Volume 9:Number 15(2021)
• Page Start: 5136
• Page End: 5143
• Publication Date: 2021-07-05
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d1bm00628b
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : Mussel-inspired adhesive mechano-activatable microcapsules have strong adhesion to a 3D fibrous matrix under aqueous conditions and are capable of delivering therapeutic cargos in response to uniaxial stretching. Abstract : Bacterial infection of a wound is a major complication that can significantly delay proper healing and even necessitate surgical debridement. Conventional non-woven fabric dressings, including gauzes, bandages and cotton wools, often fail in treating wound infections in a timely manner due to their passive release mechanism of antibiotics. Here, we propose adhesive mechanically-activated microcapsules (MAMCs) capable of strongly adhering to a fibrous matrix to achieve a self-regulated release of antibiotics upon uniaxial stretching of non-woven fabric dressings. To achieve this, a uniform population of polydopamine (PDA)-coated MAMCs (PDA-MAMCs) are prepared using a microfluidics technique and subsequent oxidative dopamine polymerization. The PDA-MAMC allows for robust mechano-activation within the fibrous network through high retention and effective transmission of mechanical force under stretching. By validating the potential of a PDA-MAMCs-laden gauze to release antibiotics in a tensile strain-dependent manner, we demonstrate that PDA-MAMCs can be successfully incorporated into a woven material and create a smart wound dressing for control of bacterial infections. This new mechano-activatable delivery approach will open up a new avenue for a stretch-triggered, on-demand release of therapeutic cargos in skin-mountable or wearable biomedical devices.