Molecular probes for selective detection of cysteine cathepsins. Issue 28 (14th April 2021)

• Record Type: Journal Article
• Authors: Schleyer, Kelton A.; Cui, Lina
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 28(2021)
• Page Start: 6182
• Page End: 6205
• Publication Date: 2021-04-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00225b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : One of these is not like the others: the 11 cysteine cathepsins have overlapping but distinct roles in pathology, and molecular probes enable their cumulative or selective detection in many applications. Abstract : Cysteine cathepsins are proteases critical in physiopathological processes and show potential as targets or biomarkers for diseases and medical conditions. The 11 members of the cathepsin family are redundant in some cases but remarkably independent of others, demanding the development of both pan-cathepsin targeting tools as well as probes that are selective for specific cathepsins with little off-target activity. This review addresses the diverse design strategies that have been employed to accomplish this tailored selectivity among cysteine cathepsin targets and the imaging modalities incorporated. The power of these diverse tools is contextualized by briefly highlighting the nature of a few prominent cysteine cathepsins, their involvement in select diseases, and the application of cathepsin imaging probes in research spanning basic biochemical studies to clinical applications.