Cohabitation With a Known Coronavirus Disease 2019 Case Is Associated With Greater Antibody Concentration and Symptom Severity in a Community-Based Sample of Seropositive Adults. (24th July 2021)

• Record Type: Journal Article
• Authors: Schrock, Joshua M; Ryan, Daniel T; Saber, Rana; Benbow, Nanette; Vaught, Lauren A; Reiser, Nina; Velez, Matthew P; Hsieh, Ryan; Newcomb, Michael; Demonbreun, Alexis R; Mustanski, Brian; McNally, Elizabeth M; D'Aquila, Richard; McDade, Thomas W
• Is Part Of: Open forum infectious diseases. Volume 8:Number 7(2021)
• Publication Date: 2021-07-24
• Subjects: immunity -- transmission -- severe acute respiratory syndrome coronavirus 2; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofab244
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: In a community-based sample of seropositive adults (n = 1101), we found that seropositive individuals who lived with a known coronavirus disease 2019 (COVID-19) case exhibited higher blood anti–severe acute respiratory syndrome coronavirus 2 spike receptor-binding domain immunoglobulin G concentrations and greater symptom severity compared to seropositive individuals who did not live with a known COVID-19 case. Abstract : Exposure intensity may contribute to severity of SARS-CoV-2 infection. Seropositive participants who had lived with a known COVID-19 case had higher antibody concentrations and greater symptom severity compared to seropositive participants who had not lived with a known COVID-19 case.